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. 2014 Apr 8;12(1):10. doi: 10.1186/1897-4287-12-10

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Copyright © 2014 Bąk et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Pedigrees of families A-E, with CHEK2 mutations. Black symbols - persons affected with cancer; white symbols with a black dot inside - healthy mutation carriers. Age of cancer or age of CHEK2 mutation diagnosis in healthy persons is given in brackets. Br - breast cancer; Lu - lung cancer; Li - liver cancer; Pr - prostate cancer; Co - colon cancer. Arrows indicate probands. I157T, IVS2 + 1G > A or 1100delC - mutation carriers; N - analyzed persons who are not carriers of the mutation; n.t. - not tested.