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Interleukin-20 receptor (IL-20R)2 co-receptor family. Ligands are shown above their respective receptors. The T104M mutation in IL-20R2 is indicated by a star with its impact on binding to IL-20, IL-19, and IL-24. Signaling through the class 2 receptor involves Janus kinase (JAK) and signal transducer and activator of transcription (STAT)3 activation through phosphorylation. Activation of STAT3 can lead to altered matrix metalloproteinase (MMP) levels and activity.
