FIG. 1.

Ex vivo pulse-induced trabecular meshwork (TM) movement and Schlemm's canal (SC) deformation in nonhuman primate eye at 8 mmHg mean intraocular pressure (IOP). Representative cross-sectional images of tissue velocity in the corneoscleral limbus: (a) red corresponds to TM movement into the SC during systole; (b) blue corresponds to TM movement away from the SC during diastole; (c) and (d) depth-dependent velocity profiles along the vertical dashed lines in (a) and (b), respectively; (e) and (f ) corresponding optical coherence tomography microstructural images from (a) and (b). (g) Enlarged view of the area marked by the dashed yellow square in (e). The closed white curve in (g) depicts the boundary of SC. (h) Schematic of the SC endothelial attachment to the underlying trabecular lamellae. The bold arrows in (h) indicate tissue responses to deforming forces induced by IOP transients. The horizontal lines are used to mark approximately the position of TM, facilitating comparison between figures. Reproduced with permission from Li et al.⁵