FIG. 2.

Heat maps depicting changes induced by myocilin mutants on the WNT pathway and Unfolded Protein Response trabecular meshwork genes. Gene lists for each pathway were custom-generated by literature review. Each row represents the fold change (Adeno.myocilin.mutant over Adeno.Null) for a single gene in each of the 4 mutants. Each column represents the fold changes for all genes of the category in one myocilin mutant. The fold change for each gene is visually represented by a color, which is given by the scale bar on the right. Gray cells indicate that the expression of the given gene was below the signal intensity cutoff value and was considered absent. Modified from reference 6 with permission.