Table 1.
Summary of the miRNAs Investigated in Trabecular Meshwork Cells
| miRNA ID (accession) | Expression changes in HTM cells | Genes downregulated in HTM cells | Cellular functions | References |
|---|---|---|---|---|
| hsa-miR-24-3p (MIMAT0000080) | Induced by mechanical stress | FURIN | TGFβ1 processing | 43 |
| hsa-miR-29b-3p (MIMAT0000100) | Downregulated by TGFβ2 and chronic oxidative stress | COL1A1, COL1A2, COL4A1, COL5A1, COL5A2, COL3A1, LAMC1, FBN1, SPARC, BMP1, ADAM12, NKIRAS2, SP1 | Extracellular matrix metabolism and TGFβ signaling | 58,60,61 |
| hsa-miR-106a-5p (MIMAT0000103) | Downregulated in senescence | p21CDKN1A | Cell proliferation, apoptosis, and senescence | 33 |
| hsa-miR-146a-5p (MIMAT0000449) | Upregulated in replicative senescence and mechanical stress | IRAK1, IL6, IL8, SERP1, CCL2 CXCL3 IL11, SLC10A3, PTGS1, GLANT10, CCL20, CXCL6, PPP2R1B, HAS1 | Retinoic acid receptor and DNA damage response | 38 |
| hsa-miR-182-5p (MIMAT0000259) | Upregulated in stress induced senescence | RARG | Cell proliferation, DNA damage response, and ITGB1 signaling | 33 |
| hsa-miR-183-5p (MIMAT0000261) | Upregulated in stress induced senescence | ITGB1, KIF2A | Production of inflammatory mediators | 37 |
| hsa-miR-200c-3p (MIMAT0000617) | Upregulated in stress induced senescence | ZEB1, ZEB2, FHOD1, EDNRA, LPAR1, RHOA | Cell contraction | 53 |
| hsa-miR-204-5p (MIMAT0000265) | Downregulated in stress induced and replicative senescence | AP1S2, BCL2L2, BIRC2, EDEM1, EZR, FZD1, M6PR, RAB22A, RAB40B, SERP1, TCF12, TCF, FOXC1, CLOCK, PLEKHG5, ITGB1 MEIS2 | Regulation of apoptosis, endoplasmic reticulum stress response, and inflammation | 35,36 |
miRNA, microRNA; HTM, human trabecular meshwork.