FIG. 2.

Alternative splicing of the human GR. The GR gene (NR3C1) contains terminal exons 9α and 9β that are alternatively spliced from the primary hnRNA transcript to generate GRα and/or GRβ mRNAs. SRps 20, 30, and 40 in the spliceosome complex are involved in this differential splicing. Exogeneous compounds [bombesin or thailanstatins (TSTs)] also regulate this alternative splicing. The GRα and GRβ mRNAs are translated to form the ligand (GC) binding GRα isoform and the dominant negative regulator isoform GRβ.