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. Author manuscript; available in PMC: 2014 Nov 6.
Published in final edited form as: J Am Chem Soc. 2013 Nov 6;135(44):16720–16735. doi: 10.1021/ja409013m

Table 3.

Optimization of the asymmetric cyano-TMM cycloaddition using oxindole 46 (R = Moc).

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a

All reactions were performed at 0.2 M in toluene with 1.5 equivalents 45, 2.5 mol% Pd2(dba)3•CHCl3 and 10 mol% ligand for 12 hours. Yields were combined, isolated product; ee’s were determined by chiral HPLC.