Table 1.
Personal, clinical, biochemical and pharmacokinetic characteristics of patients from whom mycophenolic acid trough levels were collected
| Characteristic | n = 18 | |
|---|---|---|
| Personal characteristics | ||
| Gender (female/male) | 8/10 | |
| Age (years) | 66 (30–86) | |
| Weight (kg) | 68·5 (46–97) | |
| Caucasian | 18 | |
| ANCA vasculitis | ||
| Disease duration (years) | 5·76 (0·14–14·34) | |
| BVAS score | 0 | |
| ANCA specificity (UI/ml) | PR3-ANCA (8/18) | 21·50 (0–40·00) |
| MPO-ANCA (9/18) | 3·40 (0·10–18·00) | |
| x-ANCA (1/18) | – | |
| Biochemical | ||
| Creatinine (mg/l) (n = 16)* | 14·6 (9·3–36·3) | |
| eGFR (MDRD formula) (n = 16)* | 45·5 (13·0–75·0) | |
| Proteinuria (g/l) (n = 16)* | 0·23 (0·09–1·39) | |
| Serum albumin (g/l) | 41·0 (34·0–45·0) | |
| Haemoglobin (g/dl) | 118 (84–146) | |
| White blood cells (cells/μl) | 7450 (4800−10400) | |
| Neutrophils (cells/μl) | 5135 (2420–8790) | |
| Lymphocytes (cells/μl) | 1210 (330–2480) | |
| AST (IU/l) | 17 (12–52) | |
| CRP (mg/l) | 2·3 (0–16·9) | |
| Pharmacokinetic | ||
| C0 (mg/l) | 2·40 (0·5–10·8) | |
| AUC0–9 (mg/h/l) | 41·00 (24·6–82·6) | |
| AUC0–12 (mg/h/l) | 50·55 (30·9–105·4) | |
| Dose normalized AUC0–12 (mg/h/l) | 40·75 (20·6–98·8) | |
Median values and ranges are shown. eGFR: estimated glomerular filtration rate; AST: aspartate aminotransferase; CRP: C-reactive protein; AUC: area under the curve; MDRD: Modification of Diet in Renal Disease Study; ANCA: anti-neutrophil cytoplasmic antibodies; BVAS: Birmingham Vasculitis Activity Score; PR3: proteinase 3.
*
Without patients on dialysis.