Table 3.
Correlation tests between patient immune response parameters and mycophenolic acid (MPA) pharmacokinetics [area under the curve (AUCT0–T12)]
| Immune response parameters | n = 18 | r | P |
|---|---|---|---|
| Immunoglobulins | |||
| IgA (g/l) | 1·25 (0·53–2·76) | −0·243 | 0·348 |
| IgG (g/l) | 7·12 (2·93−14·20) | −0·213 | 0·410 |
| IgM (g/l) | 0·42 (0·09–2·69) | −0·300 | 0·243 |
| Lymphocyte subsets | |||
| CD19 (mm3) | 71 (1–541) | −0·63 | <0·005 |
| CD3 (mm3) | 955 (250–1846) | −0·17 | 0·498 |
| CD4 (mm3) | 718 (149–1555) | −0·24 | 0·330 |
| CD8 (mm3) | 346 (94–943) | −0·53 | <0·05 |
| CD56 (mm3) | 106 (23–498) | −0·56 | <0·05 |
| CD4/CD8 ratio | 1·88 (0·48–5·98) | 0·168 | 0·503 |
| Complement system fractions | |||
| C3 (g/l) | 0·98 (0·74–1·51) | −0·375 | 0·126 |
| C4 (g/l) | 0·26 (0·13–0·42) | −0·184 | 0·465 |
Ig: immunoglobulin; r: Spearman's rank coefficient.