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. 2014 Apr 9;176(2):238–245. doi: 10.1111/cei.12275

Figure 5.

Figure 5

Caspase recruitment domain-containing protein 11 (CARD11) silencing reduced anti-CII antibodies and T helper type 17 (Th17) response in collagen-induced arthritis (CIA). (a) Serum level of total anti-CII-immunoglobulin (Ig)G, anti-CII IgG1 and anti-CII IgG2a antibodies. (b) Representive images of CD4+interleukin (IL)17+ Th17 cells by flow cytometry. (c) The percentage of Th17 cells in the splenocytes of CIA mice. Values are mean ± standard deviation (s.d.). #P < 0·01 versus normal control; *P < 0·05; **P < 0·01 versus control siRNA-treated group; n = eight mice per group.