Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Cellular vitamin A metabolism and signalling. Retinol is taken up from the blood via binding to Stra6. Two enzymatic oxidation steps convert retinol to retinal and subsequently into retinoic acid (RA). Upon transportation into the nucleus, RA binds to retinoic acid receptor (RAR)/ retinoic X receptor (RXR) heterodimers and these complexes regulate transcriptional activity of target genes via binding to retinoic acid response elements (RAREs) in the promoter regions.
