Figure 5.

Cowden syndrome. A: Cowden syndrome polyps are a subset of multiple hamartomatous polyps. Gastrointestinal polyps are generally benign in nature. There are associated abnormalities of the breast (carcinoma), thyroid (follicular carcinoma), and genitourinary (endometrial carcinoma) systems. B: These hamartomas are the least specific and may contain mixed tissue types of varying degrees, such as the mixed glands, vessels, and smooth muscle seen in this example (hematoxylin and eosin stain, 200× magnification).