Table.

Endoscopic and Histologic Features of Gastric Polyps

Type of Polyp	Neoplastic Potential	Location	Initial Management	Follow-up
Fundic gland polyp (sporadic or FAP)	Low	Sporadic: body, fundus FAP: covers the entire stomach	Biopsy unless >1 cm, then consider polypectomy	If no dysplasia, no follow-up If dysplastic, consider FAP diagnosis and perform colonoscopy
Hyperplastic polyp	Minimal but associated with synchronous cancers	Any location in the stomach	Biopsy or polypectomy Multiple biopsies of intervening mucosa Test and treat for Helicobacter pylori	Repeat EGD in 1 year If polyp persists or dysplasia is present, remove via polypectomy and repeat EGD in 1 year If no residual polyp, no follow-up
Adenomatous polyp	High	Any location in the stomach	Complete polypectomy Sample surrounding mucosa Examine the entire stomach for abnormalities	Incomplete resection or high-grade dysplasia: 6 months Completely resected polyp without high-grade dysplasia: 1 year
Inflammatory fibroid polyp	Very low	Antrum or prepylorus	Biopsy Remove for obstructive symptoms	No follow-up
Gastric neuroendocrine tumor (formerly carcinoid)	Depends on the type	Anywhere in the stomach I: fundus and body, clusters II: fundus and body, clusters III: anywhere in the stomach, solitary IV: anywhere in the stomach, solitary, poor prognosis	Biopsy or endoscopic removal of small lesions (<1 cm) and few numbers (3-5) for type I Random biopsies of flat mucosa	Surveillance is controversial and should be individualized I: No further follow-up if completely resected; associated with AMAG II: Consider gastrin-secreting tumor or MEN 1 syndrome III: Assess for metastasis; consider surgical removal if no metastasis IV: Assess for metastasis; consider surgical removal if no metastasis
Ectopic pancreas	None	Small submucosal mass, central umbilication	Biopsy if uncertain	No follow-up
GIST	High	Submucosal mass, central ulceration	Biopsy or FNA with EUS	Controversial; if not removed, consider follow-up with EUS
Leiomyoma	Low	Rounded submucosal lesions, rubbery feel on endoscopy	Biopsy or FNA with EUS	None if asymptomatic
Granular cell tumor	Low	Proximal stomach, yellow subepithelial nodules in submucosa	Biopsy	None if benign

The recommendations for initial management and follow-up should be followed at the discretion of the endoscopist.

AMAG, autoimmune metaplastic atrophic gastritis; EGD, esophagogastroduodenoscopy; EUS, endoscopic ultrasound; FAP, familial adenomatous polyposis; FNA, fine-needle aspiration; GIST, gastrointestinal stromal tumor; MEN, multiple endocrine neoplasia.