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. 2014 Feb 5;6(4):539–550. doi: 10.1002/emmm.201303214

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© 2014 The Authors.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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VEGFR2 blockade differentially affects adenocarcinoma (ADC) and squamous cell carcinoma (SCC) tumor cell proliferation and apoptosis.

A–D Representative images of immunohistochemical analysis of Ki67 and cleaved caspase 3 in ADC tumor-bearing mice. In the urethane-induced ADC model, sunitinib (A) and DC101 (B) reduced the tumor cell proliferation index. Increased tumor apoptosis as measured by cleaved caspase 3 staining was observed in sunitinib (C) and DC101 (D) groups. Scale bar, 25 m. Data are presented as mean ± standard error.

E–H Representative images of immunohistochemical analysis of Ki67 and cleaved caspase 3 in SCC. Sunitinib (E) and DC101 (F) treatments in SCC tumors significantly induced proliferation as compared to vehicle. The percentage of apoptotic cells was increased in the sunitinib group (G), but not in the DC101 group (H). Scale bar, 25 μm. Data are presented as mean ± standard error.