Table 3.
Unadjusted 1-, 3-, and 5-Year Post-Transplantation Survival Rates of HPS Transplant Recipients by PaO2 Category and HPS vs Non-HPS Transplant Recipients
| PaO2 category | 1-Year survival, 95% CI | 3-Year survival, 95% CI | 5-Year survival, 95% CI |
|---|---|---|---|
| Standard categories | |||
| <50 mm Hg | 87.2 (81.1–91.5) | 75.0 (66.6–81.5) | 69.3 (59.6–77.1) |
| 50–59 mm Hg | 93.1 (89.8–95.4) | 85.9 (81.0–89.6) | 80.1 (73.4–85.0) |
| 60–69 mm Hg | 87.0 (77.8–92.6) | 79.8 (68.9–87.2) | 77.7 (66.3–85.7) |
| Cubic spline categoriesa | |||
| ≤44.0 mm Hg | 84.4 (72.2–91.6) | 68.1 (52.9–79.4) | 59.0 (40.9–73.3) |
| 44.1–54.0 mm Hg | 91.8 (87.4–94.7) | 83.6 (77.4–88.2) | 77.9 (70.3–83.7) |
| 54.1–61.0 mm Hg | 92.5 (88.3–95.3) | 86.4 (80.3–90.7) | 81.7 (74.0–87.3) |
| ≥61.1 mm Hg | 84.8 (73.6–91.5) | 70.6 (57.3–80.5) | 68.4 (54.8–78.7) |
| HPS vs non-HPS recipients | |||
| All HPS recipients | 90.6 (88.1–92.6) | 81.2 (77.6–84.3) | 75.5 (71.2–79.3) |
| HPS lowest riskb | 92.3 (89.4–94.4) | 84.7 (80.6–88.1) | 79.7 (74.6–83.9) |
| Non-HPS DDLT recipients | 88.7 (88.3–89.1) | 80.7 (80.2–81.3) | 74.3 (73.6–75.1) |
DDLT, deceased donor liver transplant.
a
Cubic spline categories determined by fitting cubic spline logistic regression models for the binary outcome of post-transplantation mortality (yes/no), with pre-transplantation room-air PaO2 as a continuous variable. Cut points determined based on the best model fit. The 15 transplant recipients with a PaO2 >70 mm Hg were excluded.
b
Lowest-risk HPS transplant recipients defined as HPS transplant recipients with the best post-transplantation outcomes based on the cubic spline analysis—those with an initial room-air PaO2 of 44.1–61.0 mm Hg.