Table 5.
Multi-State Cox Regression Model Evaluating Overall Patient Survival of HPS vs Non-HPS Waitlist Candidates
| Variable | Multivariable HR (95% CI) | P valuea |
|---|---|---|
| HPS | 0.82 (0.70–0.96) | .01 |
| Age at listingb | 1.27 (1.25–1.30) | <.001 |
| Male sex | 0.97 (0.92–1.02) | .29 |
| Race/ethnicity | <.001 | |
| White | 1 | |
| Black | 1.14 (1.08–1.20) | |
| Hispanic | 0.98 (0.92–1.06) | |
| Asian | 0.97 (0.90–1.04) | |
| Other | 1.05 (0.89–1.25) | |
| Primary diagnosis | <.001 | |
| Hepatitis C | 1 | |
| Alcohol | 0.87 (0.83–0.91) | |
| Hepatitis B | 0.84 (0.77–0.92) | |
| NASH/cryptogenic | 0.88 (0.83–0.93) | |
| Cholestatic | 0.77 (0.69–0.86) | |
| Autoimmune | 0.87 (0.81–0.93) | |
| Other | 1.20 (1.08–1.33) | |
| Initial serum albumin | 0.61 (0.56–0.65) | <.001 |
| Ascites before listing | 1.49 (1.39–1.59) | <.001 |
| Receipt of transplantationc | 0.52 (0.50–0.54) | <.001 |
| Blood type | <.001 | |
| O | 1 | |
| A | 1.00 (0.96–1.04) | |
| B | 0.90 (0.85–0.96) | |
| AB | 0.86 (0.78–0.95) |
a
P value for multivariable hazard ratio.
b
Hazard for every increase in 10 years at transplantation.
c
Transition state of transplantation fit as an interaction term in the multi-state Cox model.33