Table 2.
Effects of SLC35F3 intronic variant rs17514104 on the quantitative BP traits (SBP and DBP, in mmHg) in two independent population samples: Meta-analysis.
| Group | Alleles Minor/ Major |
Minor allele frequency |
N | Trait (mmHg) |
Model | Beta (slope per allele) |
SE (of beta) |
P-value |
|---|---|---|---|---|---|---|---|---|
| KWE1 | T/C | 27.6% | 922 | SBP | T-recessive | 3.492 | 1.691 | |
| KWE2 | T/C | 27.3% | 1072 | SBP | T-recessive | 1.823 | 1.328 | |
| Meta-result | T/C | 27.5% | 1994 | SBP | T-recessive | 2.460 | 1.044 | 1.90E-02 |
| KWE1 | T/C | 27.6% | 922 | DBP | T-recessive | 1.612 | 1.392 | |
| KWE2 | T/C | 27.3% | 1072 | DBP | T-recessive | 1.979 | 0.964 | |
| Meta-result | T/C | 27.5% | 1994 | DBP | T-recessive | 1.860 | 0.792 | 1.90E-02 |
KWE1: First population BP extreme sample. KWE2: Second population sample. Covariates in these analyses were age and sex, and BP values in the hypertensives were adjusted for medications, as described in the Methods.