Table 3.
Drugs Implicated in Mixed (2 < R < 5) and Cholestatic (R ≤ 2) Reaction DILI ALF
| Cases (n) | |
|---|---|
| Mixed reactions | 12 |
| Isoniazid (alone) | 1 |
| Isoniazid, ethambutol, and pyrazinamide (combined) | 1 |
| Rifampin, ethambutol, and pyrazinamide (combined) | 1 |
| Nitrofurantoin | 3 |
| Trimethoprim/sulfamethoxazole | 1 |
| CAMs, illicit drugs, etc. | 1 |
| Fluoxetine | 1 |
| Bromfenac | 1 |
| Zafirlukast | 1 |
| Interferon β | 1 |
| Cholestatic reactions | 16 |
| Isoniazid (alone) | 2 |
| Trimethoprim/sulfamethoxazole | 1 |
| Cetopime | 1 |
| Ketoconazole | 1 |
| Phenytoin | 1 |
| Propylthiouracil | 2 |
| Melphalan | 1 |
| Bromfenac | 1 |
| Diclofenac | 1 |
| BCG | 1 |
| Cerivastatin | 2 |
| Atorvastatin | 1 |
| Methyldopa | 1 |
Abbreviation: R, ratio of relative elevation of ALT to relative elevation of alkaline phosphatase.19