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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: J Neurochem. 2013 Nov 25;129(1):48–59. doi: 10.1111/jnc.12527

Figure 5. Schema: Reciprocal actions of CHGB on catecholamine storage (stimulation) and release (inhibition).

Figure 5

The figure synthesizes the consequences of our CHGB results for these physiological processes. Within chromaffin cells, CHGB participates in assembly of catecholamine secretory vesicles (dense-core granules), and governs the secretory capacity of these granules under the nicotinic stimulation. After proteolytic cleavage and release into the extracellular space, CHGB (and particularly its peptide hCHGB[60–67]) seems to exert a negative feedback effect to inhibit the secretory response to acetylcholine.