Table 3. Univariate Analysis of Factors Associated with Survival.
| Variable | Median survival in months (95% CI) | p-value | ||
|---|---|---|---|---|
| Log-Rank | Wilcoxon | |||
| Management of perforation | Surgical (n=28) | 11.43 (2.60-20.77) | 0.24 | 0.02 |
| Conservative (n=15) | 1.93 (0.20-**) | |||
| Extent of cancer present at the time of perforation | No evidence of disease (n=8) | 128.07 (3.57-128.07) | <0.0001 | <0.0001 |
| Microscopic disease/Localized disease (n=10) | 25.13 (6.47-**) | |||
| Peritoneal carcinomatosis/Distant metastasis (n=22) | 0.87 (0.30-1.93) | |||
| Cancer-directed surgery | Yes (n=31) | 4.20 (1.13-12.23) | 0.02 | 0.06 |
| No (n=11) | 128.07 (0.40-128.07) | |||
| Number of chemotherapy regimens | <2 (n=17) | 16.17 (3.57-**) | 0.03 | 0.004 |
| ≥2 (n=14) | 0.87 (0.20-1.87) | |||
| None/Unknown (n=12) | 10.92 (0.40-32.43) | |||
| Stage | I/II (n=16) | 32.43 (6.47-128.07) | 0.002 | 0.005 |
| III/IV (n=21) | 2.57 (0.40-10.97) | |||
| Unknown (n=6) | 1.73 (0.10-17.83) | |||
| CA-125 | <100 (n=10) | 10.87 (0.40-**) | 0.004 | 0.002 |
| ≥100 (n=16) | 1.17 (0.20-4.20) | |||
| Unknown (n=17) | 17.83 (3.57-128.07) | |||
**
Number of events too small to obtain an estimate.
¶
Both log-rank and Wilcoxon methods were used for statistical analysis as the data were not normally distributed due to a small sample size.