. Author manuscript; available in PMC: 2014 Apr 21.

Published in final edited form as: J Allergy Clin Immunol. 2008 Jun 24;122(2):335–341.e3. doi: 10.1016/j.jaci.2008.05.020

TABLE II. Airway structural changes in asthma and EB.

			Asthma (n = 42)
	Control (n = 19)	Eosinophilic bronchitis (n = 21)	GINA 1 (n = 17)	GINA 2-4 (n = 15)	Refractory (n = 10)
RBM thickness (μm)	6.6 (0.4)	11.1 (0.96)^†	9.5 (0.77)^†	8.9 (1.1)	11.0 (0.7)^*^†
Percent ASM	8.5 (1.3)	17.9 (3.4)^†	17.2 (1.9)^†	16.1 (3.6)	16.3 (2.8)^*^†
Percent glands	1.6 (0.61)	3.1 (1.4)	0.82 (0.3)	2.4 (1.5)	4.9 (1.6)
Percent collagen 3 lamina propria	8.9 (2.3)^‡	7.4 (2.1)^†	2.6 (1.3)	1.4 (0.4)	6.9 (2.3)^*^‡
Collagen 3 SQS lamina propria	2.02 (0.2)	2.36 (0.15)	1.85 (0.27)	1.68 (0.16)^§	2.23 (0.30)
Collagen 3 SQS ASM (mean score)	0.56 (0.1)	0.68 (0.08)	0.58 (0.14)	0.43 (0.11)	0.68 (0.13)
Collagen 3 SQS ASM (number positive)	7/18	6/14	5/10	7/15	7/10
Mast cells/mm² ASM	3.1 (0.63)	1.03 (0.41)	8.8 (2.3)^†^§	11.7 (2.3)^†^§	15.6 (2.6)^*^†^§

SQS, Semiquantitative score.

Data expressed as means (SEMs).

P < .05 1-way ANOVA; normal vs EB/GINA 1, GINA 2-4, refractory asthma.

^†

P < .05 vs control (Mann-Whitney tests/t tests for intergroup comparisons).

^‡

P < .05 vs GINA 2-4 asthma (Mann-Whitney tests/t tests for intergroup comparisons).

^§

P < .05 vs EB (Mann-Whitney tests/t tests for intergroup comparisons).