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. 2013 Mar 6;35(16):1078–1087. doi: 10.1093/eurheartj/eht067

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© The Author 2013. Published by Oxford University Press on behalf of the European Society of Cardiology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial use, distribution, and reproduction in any medium, provided that the original authorship is properly and fully attributed; the Journal, Learned Society and Oxford University Press are attributed as the original place of publication with correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oup.com

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Isoprenaline and E4031 drug treatment in siRNA-treated long-QT syndrome-type 2 cardiomyocytes. (A) (i) Averaged and (ii) raw data of isoprenaline-induced arrhythmias in the form of early-afterdepolarizations observed only in control long-QT syndrome-type 2 cardiomyocytes (n = 10). (B). (i) Isoprenaline (100 nM, n = 10) or (ii) E4031 (1 µM, n = 5) treatment in A13-treated long-QT syndrome-type 2 cardiomyocytes did not cause early-afterdepolarizations, depicting rescue of long-QT syndrome-type 2-phenotype by RNAi-based therapy.