Table 1.

Cox regression analyses according to proteinuria status, reference = no proteinuria group.

	Age-Adjusted			Fully-Adjusted *
	HR	95%CI	p value	HR	95%CI	p value
Entire Cohort (n=6,815)
Transient Proteinuria vs. None	1.55	1.40–1.71	<0.001	1.40	1.26–1.55	<0.001
Persistent Proteinuria vs. None	2.50	2.01–3.10	<0.001	2.26	1.81–2.84	<0.001
P for trend			<0.001			<0.001
Positive Proteinuria ** vs. None	1.65	1.51–1.81	<0.001	1.49	1.36–1.64	<0.001
STRATIFIED ANALYSES – Comparing Positive Proteinuria ** to No Proteinuria
Non-Hypertensives (n=3,206)	1.47	1.25–1.72	<0.001	1.40	1.19–1.65	<0.001
Hypertensives (n=3,608)	1.70	1.52–1.90	<0.001	1.54	1.37–1.73	<0.001
Non-Diabetics (n=5,750)	1.53	1.38–1.70	<0.001	1.40	1.25–1.56	<0.001
Diabetics (n=1,065)	1.98	1.65–2.37	<0.001	1.85	1.53–2.25	<0.001
CVD *** Not Present (n=2,621)	1.44	1.20–1.73	<0.001	1.32	1.09–1.59	0.004
CVD Present (n=4,194)	1.67	1.50–1.86	<0.001	1.56	1.40–1.74	<0.001

^*Adjusted for age, body mass index, hypertension, diabetes mellitus, pack-years smoking, physical activity index, serum cholesterol, alcohol intake, and prevalent coronary heart disease, stroke, and cancer, except for specific risk factors used for each stratified analysis.

^**Positive Proteinuria = transient or persistent proteinuria (combined).

^***CVD = cardiovascular diseases at baseline, including hypertension, diabetes, coronary heart disease, or stroke.