Table 2. Discriminative cutoff values in relative expression units (REU) for the functional pathway components.

		Patient deviation (%)
Protein	Cutoff value	Negative	Positive
Akt	204	44 (37)	74 (63)
Phospho-Akt	104	77 (65)	41 (35)
GSK-3beta	151	20 (17)	98 (83)
mTOR	157	80 (68)	38 (32)
Phospho-mTOR	114	28 (24)	90 (76)
PI3K	114	23 (19)	95 (81)
Phospho-PI3K	152	56 (47)	62 (53)
S6RP	329	45 (38)	73 (62)
Phospho-S6RP	107	72 (61)	46 (39)
4E-BP1	291	97 (82)	21 (18)
Phospho-4E-BP1	121	86 (73)	32 (27)

Abbreviations: mTOR=mammalian target of rapamycin; S6RP=S6 ribosomal protein.