Table 3. Pair-wise analysis of phospho-Akt, S6RP, phosphor-4E-BP1 and grading by Cox-regression (disease-free survival).

			95% CI for Exp (B)
Factor	Against	Exp	Min	Max	Significance
Phospho-Akt	S6RP	3.459	1.012	11.820	0.048
	Phospho-4E-BP1	2.702	0.630	11.589	0.181
	Histograding	3.439	1.006	11.757	0.049
S6RP	Phospho-Akt	4.440	0:512	38.546	0.176
	Phospho-4E-BP1	4.235	0.490	36.589	0.190
	Histograding	6.270	0.802	49.025	0.080
Phospho-4E-BP1	Phospho-Akt	4.067	1.241	13.330	0.021
	S6RP	4.067	1.241	13.330	0.021
	Histograding	4.067	1.241	13.330	0.021
Histograding	Phospho-Akt	3.688	1.124	12.095	0.031
	S6RP	3.688	1.124	12.095	0.031
	Phospho-4E-BP1	3.490	1.062	11.467	0.040

Abbreviations: CI=confidence interval; mTOR=mammalian target of rapamycin; S6RP=S6 ribosomal protein.

Parameter phospho-Akt expression lower than 104 RIU versus higher than 104 RIU; S6RP expression lower than 329 RIU versus higher than 329 RIU; phospho-4E-BP1 expression lower than 121 RIU versus higher than 121 RIU; Grading G1 and G2 versus G3. Statistically significant values are depicted in bold italic letters.