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. 2014 Mar 18;110(8):2000–2010. doi: 10.1038/bjc.2014.141

Figure 5.

Figure 5

PPP2CA overexpression decreases tumourigenicity of PCa cells in orthotopic mice model. PC3 (control and PPP2CA-overexpressing) cells were injected into the prostate of mice (n=8 per group) and killed after 30 days. (A) Volume and (B) weight of the tumours from the each animal of the control and PPP2CA-overexpressing group were calculated. Dark line indicates the median value of the respective group. (C) Immunohistological analysis of paraffin-embedded prostate tumours for PP2Acα expression (left panel), Ki67 expression (a proliferative marker; middle panel) and TUNNEL assay (right panel). (D). Number of proliferating (upper panel) and apoptotic (lower panel) cells were counted in 10 random view fields (magnification × 100) in a double-blinded manner and expressed as mean±s.d., n=3, per field view. *P<0.01.