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. 2014 Feb 20;110(8):1977–1984. doi: 10.1038/bjc.2014.91

Figure 2.

Figure 2

Durability of PARP inhibition following a short pulse of rucaparib. (A) Parallel measurements of rucaparib retention and PARP inhibition in SW620 cells for up to 3 days following a 30-min exposure to 400 nM [14C]rucaparib, followed by transfer to drug-free medium. Data are mean and s.e.m. from three independent experiments. (B) Poly(ADP-ribose) polymerase-1 inhibition in Capan-1 and MX-1 cells for up to 7 days after exposure to a 30-min pulse of 400 nM rucaparib, data are from a single representative experiment. (C) Survival of Capan-1 (BRCA2 mutant) and MX-1 (BRCA1 mutant) cells following 24 h exposure to increasing concentrations of rucaparib then transfer to fresh medium for colony formation, data are mean of two independent experiments.