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Pharmacokinetics of rucaparib in Capan-1 tumour-bearing mice. Concentrations of rucaparib in plasma (A), tumour (B) and brain (C) at various times up to 1 week after a single dose of rucaparib either 10 mg kg−1 i.p. (filled circles) 50 mg kg−1 p.o. (open circles), 100 mg kg−1 p.o. (filled triangles) or 150 mg kg−1 p.o. (open triangles). Data are individual values from three mice per group.
