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. 2014 Feb 20;110(8):1977–1984. doi: 10.1038/bjc.2014.91

Figure 4.

Figure 4

Poly(ADP-ribose) polymerase-1 activity in tumour, brain and PBMCs following a single dose of rucaparib. Poly(ADP-ribose) polymerase-1 activity was determined in homogenates of Capan-1 tumours and brains of mice at various times up to 1 week after a single dose of rucaparib either 10 mg kg−1 i.p. (filled circles) 50 mg kg−1 p.o. (open circles), 100 mg kg−1 p.o. (filled triangles) or 150 mg kg−1 p.o. (open triangles). Data are mean±s.e.m. from three mice per group. (C) Plasma rucaparib levels and PARP activity in PBMCs were determined following a single injection of rucaparib (10 mg kg−1 i.p.). Data are mean±s.e.m. from three mice per time point (PBMC triplicates from pooled blood of three mice per time point).