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Multiple CYP11B1 COBALT (NCBI) alignments. The Arg143, Ala306, Glu310 and Arg332 residues of CYP11B1 and corresponding amino acids of the aligned CYPs are shaded. (a) Alignment of human CYP11B1 with human CYP11B2, the mouse, rat and macaca orthologues. (b) Alignment of different human steroidogenic CYP enzymes (type I enzymes, CYP11B1, CYP11B2, CYP11A1; type II enzymes, CYP21A2, CYP17A1, CYP19A1).
