Table 3. Single marker meta-analysis in the ‘CE' and ‘All' samples. Association results are given for the case–control analysis and for both quantitative measurements, word-reading and spelling.
| Case–Control | Word-readinga | Spellinga | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ‘CE' sample | ‘All' sample | ‘CE' sample | ‘All' sample | ‘CE' sample | ‘All' sample | |||||||||
| SNP | Gene | Reference allele | Z | P | Z | P | Z | P | Z | P | Z | P | Z | P |
| rs1000585 | MRPL19/C2ORF3 | G | −0.60 | 5.51 × 10−01 | 0.18 | 8.59 × 10−01 | −0.16 | 8.70 × 10−01 | −0.99 | 3.23 × 10−01 | 0.47 | 6.42 × 10−01 | 0.10 | 9.20 × 10−01 |
| rs917235 | MRPL19/C2ORF3 | G | −0.16 | 8.75 × 10−01 | −0.22 | 8.27 × 10−01 | 0.87 | 3.85 × 10−01 | −0.32 | 7.49 × 10−01 | 0.83 | 4.06 × 10−01 | 0.07 | 9.48 × 10−01 |
| rs714939 | MRPL19/C2ORF3 | A | −0.21 | 8.36 × 10−01 | −0.11 | 9.13 × 10−01 | 1.69 | 9.17 × 10−02 | 1.49 | 1.35 × 10−01 | 1.22 | 2.23 × 10−01 | 0.51 | 6.13 × 10−01 |
| rs6732511 | MRPL19/C2ORF3 | T | 0.35 | 7.25 × 10−01 | −0.05 | 9.59 × 10−01 | 0.23 | 8.20 × 10−01 | −0.17 | 8.65 × 10−01 | −0.72 | 4.74 × 10−01 | −0.94 | 3.47 × 10−01 |
| rs793862 | DCDC2 | A | 1.10 | 2.71 × 10−01 | 1.30 | 1.94 × 10−01 | 0.24 | 8.14 × 10−01 | −0.03 | 9.77 × 10−01 | −1.69 | 9.03 × 10−02 | −1.66 | 9.65 × 10−02 |
| rs807701 | DCDC2 | C | 0.82 | 4.11 × 10−01 | 0.69 | 4.90 × 10−01 | 1.56 | 1.20 × 10−01 | 0.79 | 4.31 × 10−01 | −0.95 | 3.35 × 10−01 | −0.69 | 4.87 × 10−01 |
| rs807724 | DCDC2 | G | 0.96 | 3.38 × 10−01 | 1.44 | 1.50 × 10−01 | 0.88 | 3.77 × 10−01 | 0.13 | 8.95 × 10−01 | −1.35 | 1.78 × 10−01 | −1.39 | 1.65 × 10−01 |
| rs4504469 | KIAA0319 | T | 0.48 | 6.31 × 10−01 | −0.82 | 4.11 × 10−01 | −0.03 | 9.74 × 10−01 | 0.36 | 7.18 × 10−01 | −2.73 | 6.30 × 10−03 | −1.79 | 7.30 × 10−02 |
| rs2179515 | KIAA0319 | A | 1.03 | 3.02 × 10−01 | 0.28 | 7.77 × 10−01 | −0.40 | 6.90 × 10−01 | −0.99 | 3.23 × 10−01 | −2.06 | 3.92 × 10−02 | −1.17 | 2.41 × 10−01 |
| rs761100 | KIAA0319 | T | 0.16 | 8.76 × 10−01 | −0.13 | 8.97 × 10−01 | −0.73 | 4.67 × 10−01 | −1.32 | 1.88 × 10−01 | −2.26 | 2.35 × 10−02 | −1.85 | 6.39 × 10−02 |
| rs6935076 | KIAA0319 | T | 0.06 | 9.54 × 10−01 | 0.09 | 9.28 × 10−01 | 0.62 | 5.32 × 10−01 | 0.93 | 3.52 × 10−01 | 2.35 | 1.89 × 10−02 | 1.70 | 8.95 × 10−02 |
| rs3212236 | KIAA0319 | G | −0.42 | 6.75 × 10−01 | −0.30 | 7.61 × 10−01 | 0.22 | 8.23 × 10−01 | 0.39 | 6.97 × 10−01 | 0.02 | 9.87 × 10−01 | −0.28 | 7.82 × 10−01 |
| rs9461045 | KIAA0319 | T | −0.41 | 6.83 × 10−01 | −0.20 | 8.40 × 10−01 | 0.16 | 8.73 × 10−01 | −0.82 | 4.15 × 10−01 | 0.13 | 8.98 × 10−01 | 0.23 | 8.22 × 10−01 |
| rs2143340 | KIAA0319 | C | −0.67 | 5.04 × 10−01 | −0.31 | 7.54 × 10−01 | 0.00 | 9.98 × 10−01 | −0.66 | 5.08 × 10−01 | 0.90 | 3.71 × 10−01 | 1.14 | 2.53 × 10−01 |
| rs57809907 | DYX1C1 | A | 0.82 | 4.14 × 10−01 | 0.91 | 3.64 × 10−01 | 1.17 | 2.40 × 10−01 | 0.75 | 4.53 × 10−01 | 0.30 | 7.62 × 10−01 | 0.30 | 7.64 × 10−01 |
| rs17819126 | DYX1C1 | T | 0.18 | 8.58 × 10−01 | 0.08 | 9.35 × 10−01 | 0.99 | 3.23 × 10−01 | 0.50 | 6.14 × 10−01 | −0.43 | 6.64 × 10−01 | −0.59 | 5.55 × 10−01 |
| rs3743204 | DYX1C1 | T | 0.73 | 4.67 × 10−01 | 0.91 | 3.65 × 10−01 | 2.38 | 1.72 × 10−02 | 1.52 | 1.28 × 10−01 | 1.02 | 3.08 × 10−01 | 0.32 | 7.47 × 10−01 |
| rs3743205 | DYX1C1 | T | 1.20 | 2.32 × 10−01 | 0.78 | 4.37 × 10−01 | 1.47 | 1.42 × 10−01 | 0.48 | 6.34 × 10−01 | 1.77 | 7.60 × 10−02 | 1.50 | 1.35 × 10−01 |
Nominal significant P-values <0.05 are depicted in bold, Bonferroni-corrected P-value is 0.00072 (=0.05/69).
Z defines the test-statistic of the meta-analysis.
a
Only the dyslexia cases were analysed.