Table 4. Haplotype meta-analysis in the ‘CE' and ‘All' sample. Association results are given for the case-control analysis and for both quantitative measurements, word-reading and spelling.
| Case–Control | Word-readinga | Spellinga | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ‘CE' sample | ‘All' sample | ‘CE' sample | ‘All' sample | ‘CE' sample | ‘All' sample | |||||||||
| SNP combination | Haplotype | Gene | Z | P | Z | P | Z | P | Z | P | Z | P | Z | P |
| rs917235-rs714939 | GG | MRPL19/C2ORF3 | 0.59 | 5.58 × 10−01 | 0.35 | 7.30 × 10−01 | −0.88 | 3.79 × 10−01 | −0.91 | 3.60 × 10−01 | −0.3 | 5.58 × 10−01 | −0.01 | 9.93 × 10−01 |
| rs1000585-rs917235-rs714939 | GGG | MRPL19/C2ORF3 | 0.02 | 9.82 × 10−01 | 0.01 | 9.92 × 10−01 | −1.52 | 1.29 × 10−01 | −1.36 | 1.74 × 10−01 | −0.12 | 9.82 × 10−01 | 0.54 | 5.92 × 10−01 |
| rs917235-rs714939-rs6732511 | GGC | MRPL19/C2ORF3 | 0.21 | 8.33 × 10−01 | 0.35 | 7.28 × 10−01 | −1.22 | 2.24 × 10−01 | −0.95 | 3.40 × 10−01 | 0.67 | 8.33 × 10−01 | 1.08 | 2.80 × 10−01 |
| rs793862-rs807701 | AC | DCDC2 | 0.88 | 3.81 × 10−01 | 1.24 | 2.15 × 10−01 | 0.37 | 7.09 × 10−01 | −0.33 | 7.41 × 10−01 | −1.24 | 3.81 × 10−01 | −1.08 | 2.79 × 10−01 |
Nominal significant P-values <0.05 are depicted in bold, Bonferroni-corrected P-value is 0.00072 (=0.05/69).
Z defines the test statistic of the meta-analysis.
Only the dyslexia cases were analysed.