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A simplified biosynthetic route to representative angucyclines and the phenotypic responses of S. coelicolor to various angucyclines. (A) A simplified biosynthetic route to representative angucyclines; the key structures are numbered in brackets. (B) The phenotypic responses of S. coelicolor to various angucyclines on SMM plates. The angucyclines were dissolved in 100% DMSO, and 10 μL (10 mM) was spotted on a lawn of S. coelicolor grown on SMM.
