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. 2014 Mar 31;111(15):5664–5669. doi: 10.1073/pnas.1319051111

Fig. 6.

Fig. 6.

Gr-1+ cell depletion reduces the growth of lung adenocarcinoma. CC-LR mice were treated every 3 d for 2 wk with anti–Gr-1 or isotype control antibody. (A) Flow cytometric analyses of Gr-1+CD11b+ in BALF and lung. Cells were gated in FSChi SSChi. (B) Tumor burden after anti–Gr-1 treatment (control Ig, n = 5; anti–Gr-1, n = 8). (C) Representative sections of lung adenocarcinoma immunostained with Ki67 or CD31. Ki67-positive cells or CD31 positive cells per 100 tumor cells (circle, control Ig; square, anti–Gr-1). (D) Relative expression of mRNA in whole lungs after anti–Gr-1 treatment in CC-LR mice. Data are expressed as fold increase compared with controls. Data represent means ± SEM *P < 0.05, **P < 0.01, ***P < 0.001.