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. 2014 Mar 31;111(15):5652–5657. doi: 10.1073/pnas.1321803111

Fig. 2.

Fig. 2.

Mtv+ Vβ5 Tg mice have elevated memory B-cell formation and high-affinity Ab production during a primary Ab response. (A, Left to Right) The % memory (CD62L+MHC class II+CD73+CD80+), % memory with unmutated Ig (CD35+), and % memory with mutated Ig (CD35−) of B220+ B cells in mLN from Vβ5 Tg Mtv+ (black), TCR non-Tg Mtv+ (white), and Vβ5 Tg Mtv− (gray) mice ranging from 28 to 45 wk of age. (B, Left and Center) Titrations of NP-specific IgM and IgG Ab. (Right) Ratio of high-affinity IgG to total IgG (1:100 dilution) in sera from Vβ5 Tg Mtv+ (black) and Mtv− (gray) mice ranging from 15 to 17 wk of age 21 d after primary immunization with NP-KLH (Upper) or 7 d after secondary immunization with NP-CGG (Lower). Bars indicate mean ± SEM from three to seven mice per group in one to five independent experiments. *P < 0.05, **P < 0.01, ***P < 0.005.