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. 2013 Oct 30;44(1):127–136. doi: 10.1002/eji.201343593

Figure 2.

Figure 2

Increased MMP concentrations in PBMC culture supernatants from IRIS patients MMP concentrations were assayed in the PBMC culture supernatants arising from 20 TB-IRIS at the time of TB-IRIS and 20 non-TB-IRIS participants after a similar duration of antitubercular and antiretroviral therapy. The MMP concentrations shown are background subtracted, values being the (delta) difference between stimulated and unstimulated cultures. The delta MMP concentrations of IRIS versus non-IRIS was compared using the Mann–Whitney test. Concentrations of MMP-1,-3,-7, and-10 were found to be significantly higher in the TB-IRIS compared with controls (pcorr = 0.05). Closed circles represent TB-IRIS patients while open circles represent the non-IRIS controls. Each symbol represents an individual patient and bars represent median values with only significant p-values (p ≤ 0.0.5) shown on the relevant panels.