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. 2013 Oct 30;44(1):127–136. doi: 10.1002/eji.201343593

Figure 4.

Figure 4

Prednisone tends to suppress circulating MMP concentration in TB-IRIS patients. To assess the effect of steroid therapy on circulating MMP protein concentrations in vivo, (in serum samples) 14 prednisone-treated and 8 placebo-treated TB-IRIS participants were assessed for those MMPs that were higher in IRIS in cell culture supernatants, i.e. MMP-1, MMP-3, and MMP-7. MMP concentrations for each treatment group at the 2-and 4-week time points were analyzed by the Wilcoxon matched-pairs signed rank test. Prednisone tended to suppress MMP-7 concentrations after 2 weeks of therapy although this did not reach statistical significance after correcting for multiple comparisons (p = 0.2). In this figure, open circles represent the placebo-treated patients while closed circles represent the steroid (prednisone) treated IRIS patients. Each symbol represents an individual patient.