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. Author manuscript; available in PMC: 2014 Apr 21.
Published in final edited form as: Matrix Biol. 2010 Aug 18;29(8):645–656. doi: 10.1016/j.matbio.2010.08.001

Fig. 3.

Fig. 3

Role of the extracellular matrix and microenvironment in lymphangiogensis in tumors. Growth factors and cytokines produced by tumor cells and stroma are transported by fluid flow and down a diffusion gradient to lymphatics and blood capillaries. Tumor and immune cells (expressing CCR7) are chemoattracted to and enter peritumoral initial lymphatics expressing CCL19/21. + (plus) and − (minus) denotes stimulating and inhibiting lymphangiogenesis, respectively. x-collagen: crosslinked collagen, Pif: interstitial fluid pressure, CAF: cancer associated fibroblast.