Table 3. Summary of meta-analysis.

Toxicity	Compared genotype	Group	No. of studies	No. of participants	Odds ratios (ORs) 95% confidence intervals (CI)	P-value	Test for heterogeneity
							P-value	I2(%)
Neutropenia	*28/*28 vs *1/*1	Total	13	1095	4.79 [3.28, 7.01]	<0.00001	0.20	22
		+5FU subgroup	12	932	4.67 [3.11, 7.00]	<0.00001	0.14	30
		−5FU subgroup	3	163	5.87 [1.97, 17.42]	<0.001	0.41	0
		High IRI subgroup	9	764	4.64 [2.88, 7.17]	<0.00001	0.06	44
		Low IRI subgroup	6	331	6.37 [2.69, 10.71]	<0.00001	0.76	0
	*1/*28 vs 1/*1	Total	14	1819	1.90 [1.44, 2.51]	<0.00001	0.98	0
		+5FU subgroup	13	1573	1.87 [1.39, 2.51]	<0.0001	0.93	0
		−5FU subgroup	3	246	2.18 [0.91, 5.22]	0.08	0.85	0
		High IRI subgroup	9	1189	1.85 [1.32, 2.58]	0.0003	0.98	0
		Low IRI subgroup	7	630	2.01 [1.21, 3.34]	0.007	0.61	0
	*28/*28 vs *1/*28 or *1/*1	Total	14	2015	3.44 [2.45, 4.82]	<0.00001	0.15	26
		+5FU subgroup	13	1740	3.40 [2.37, 4.88]	<0.00001	0.14	29
		−5FU subgroup	3	275	3.70 [1.46, 9.40]	0.006	0.20	38
		High IRI subgroup	9	1311	3.34 [2.21, 5.05]	<0.00001	0.02	54
		Low IRI subgroup	7	704	3.63 [2.02, 6.53]	<0.00001	0.96	0
Diarrhoea	*28/*28 vs *1/*1	Total	13	1122	1.84 [1.24, 2.72]	0.002	0.15	27
		+5FU subgroup	12	913	1.78 [1.16, 2.75]	0.009	0.07	41
		−5FU subgroup	4	209	2.09 [0.83, 5.26]	0.12	0.56	0
		High IRI subgroup	8	774	2.37 [1.39, 4.04]	0.002	0.31	15
		Low IRI subgroup	6	348	1.41 [0.79, 2.51]	0.24	0.12	42
	*1/*28 vs 1/*1	Total	13	1794	1.20 [0.93, 1.56]	0.16	0.55	0
		+5FU subgroup	12	1472	1.19 [0.89, 1.58]	0.25	0.46	0
		−5FU subgroup	4	322	1.28 [0.71, 2.30]	0.41	0.44	0
		High IRI subgroup	8	1201	1.39 [0.97, 1.98]	0.07	0.65	0
		Low IRI subgroup	6	593	1.02 [0.70, 1.50]	0.91	0.36	8
	*28/*28 vs *1/*28 or *1/*1	Total	13	1980	1.71 [1.18, 2.47]	0.005	0.29	14
		+5FU subgroup	12	1626	1.67 [1.11, 2.52]	0.01	0.17	28
		−5FU subgroup	4	354	1.85 [0.77, 4.43]	0.17	0.53	0
		High IRI subgroup	8	1317	2.04 [1.23, 3.38]	0.006	0.41	3
		Low IRI subgroup	6	663	1.41 [0.82, 2.43]	0.21	0.20	31

Abbreviations: FU, fluorouracil; IRI, irinotecan.