Table 4.
Putative immunity-related target genes for M. sexta miRNAs
| Name | Putative Targets |
|---|---|
| mse-miR-1 | ANKRD54, cecropin-like, Draper, Hdd13, Tab2, tetraspanin |
| mse-miR-1b | Aminoacylase, PPBP1, MASK |
| mse-miR-2a | Aop, Atg6, Domeless, galectin-2, Hdd23, Pelle, PI-like, salivary cysteine-rich peptide |
| mse-miR-2b | Aop, Atg6, Domeless, galectin-2, Hdd23, Pelle, PI-like, salivary cysteine-rich peptide |
| mse-miR-7 | Aop, ERK, focal adhesion kinase, galectin-4, Hdd13, HP12, JAK/Hopscotch, MyD88, serpin4, tyrosine protein kinase |
| mse-miR-8 | aPKC, cdc42, ERK, focal adhesion kinase, HP17, HP17s, integrin linked protein kinase, Jra, MLK1, p38, PPBP2, Pelle, PPO2, protein phosphatase type 2c, salivary cysteine-rich peptide, Serrate, Tollip |
| mse-miR-9a | Brahma, Cactus, cecropin-like, CTL10, Domeless, Eiger, FADD, GTP/GDP exchange factor, Hdd1, HP17, HP17s, HP21, HP5, integrin β1, moricin, PAP2, PSP, Punch, Rac1, thioredoxin peroxidase-3, transferrin, tyrosine protein kinase |
| mse-miR-9b | Alk, Domeless, Draper, HP22, HP7, Imd, p38, protein phosphatase type 2c, PVR, serpin4 |
| mse-miR-10a | aPKC, βGRP3, cecropin-like, Domeless, PGRP-L2, Phe hydroxylase, PI6, Spz1A, Spz1B, STAT, Tab2, TAK1 |
| mse-miR-11 | Aop, attacin1, Brahma, Domeless, Dsor1, FADD, HP12, HP14, HP8, IKKβ, integrin related 1, JAK/Hopscotch, lectin, Misshapen, PPBP2, PGRP-L2, protein phosphatase type 2c, PPO1, PSP, Ref2P, serpin4, serpin6, Tab2, tetraspanin |
| mse-miR-12 | Aminoacylase, βGRP2, cecropin B, HP5, HP6, IKKβ, MLK1, PAP3, PPBP2, serpin3, tetraspanin, thioredoxin peroxidase-3 |
| mse-miR-14 | ANKRD54, Dicer-2, HP7, JAK/Hopscotch, MEKK1, PGRP-L5, Stam, tetraspanin, thioredoxin peroxidase-3 |
| mse-miR-31 | ECSIT, MEKK1, Rel2B |
| mse-miR-33 | Alk, JAK/Hopscotch, Notch |
| mse-miR-34 | cdc42, Draper, ERK, Hdd13, Hem, integrin β1, integrin related-1, JNK, MKK4, nuclear transport factor 2, Serrate, tetraspanin, Ubc13/ben |
| mse-miR-71 | Atg4LP, Domeless, Dscam, gallerimycin, Lesswright, MKK4, MLK1, MyD88, PAP2, PGRP-L2, PGRP-L5, Punch, Rel2A |
| mse-miR-79 | Alk, Domeless, Draper, HP2, p38, protein phosphatase type 2c, serpin4 |
| mse-miR-87 | Draper, FADD, HP13, IML3, Spz1A, Spz1B, Tab2, tetraspanin, Tollip |
| mse-miR-92b | Dsor1, HP13, HP2, JAK/Hopscotch, JNK, leureptin 1, MLK1, MyD88, neuroglian, Rel2A, STAT |
| mse-miR-100 | Argonaute-1, MyD88 |
| mse-miR-184 | HP12, p38 |
| mse-miR-190 | Dicer-2, focal adhesion kinase, PGRP-L2, PPO1 |
| mse-miR-252 | Cecropin-like, Dicer-2, Domeless, Hdd1, Hdd13, IKKβ, integrin β1, Jra, PAP2, Ref2P, scolexinB |
| mse-miR-263a | ANKRD54, Atg4, Cactus, Draper, ECSIT, Eiger, HP14, integrin linked protein kinase, Licrone/MKK3, protein phosphatase type 2c, PSP precursor, serpin3, serpin4, tetraspanin |
| mse-miR-275 | HP12, integrin β1, PIAS, protein phosphatase type 2c, Rac1, Spz1A, Spz1B, tetraspanin, tyrosine protein kinase, Uba2 |
| mse-miR-276 | Domeless, Dsor1, IML3, leureptin 1, secreted peptide 30, Tab2 |
| mse-miR-277 | Aop, Atg3, Domeless, Draper, Dscam, Dsor1, ERK, focal adhesion kinase, galectin-2, HP12, HP13, HP6, HP8, IAP, JAK/Hopscotch, Lesswright, MEKK1, MKK4, p38, protein phosphatase type 2c, Rac1, serpin2, serpin4, Sickie, SPH2, tetraspanin, tyrosine protein kinase |
| mse-miR-279a | GTP/GDP exchange factor, HP12, integrin related 1, integrin linked protein kinase, protein phosphatase type 2c, Rac1, tetraspanin, Ubc13/ben |
| mse-miR-279b | Atg4, GTP/GDP exchange factor, HP12, integrin related 1, integrin linked protein kinase, protein phosphatase type 2c, Rac1, Ubc13/ben |
| mse-miR-279c | GTP/GDP exchange factor, IKKγ, integrin related 1, integrin linked protein kinase, protein phosphatase type 2c, tetraspanin, Ubc13/ben |
| mse-miR-279d | Atg4, GTP/GDP exchange factor, Hdd1, HP12, HP6, IKKγ, integrin related 1, integrin linked protein kinase, protein phosphatase type 2c, scolexinB, tetraspanin, Ubc13/ben |
| mse-miR-281 | aPKC, Dsor1, PPBP2 |
| mse-miR-282 | galectin-2, Hdd1, PGRP-L2 |
| mse-miR-283 | Atg3, Atg4, Atg4LP, attacin1, attacin3, Domeless, galectin-4, GTP/GDP exchange factor, Hdd1, IKKβ, Imd, integrin related 1, integrin linked protein kinase, JAK/Hopscotch, lebocin B, Misshapen, MLK1, Notch, Nuclear transport factor 2, PPBP2, PGRP-L2, protein phosphatase type 2c, PSP, Punch, PVR, Rel2A, Tab2, tyrosine hydroxylase |
| mse-miR-306 | HP12, PIAS, Rac1, Spz1A, Spz1B, Uba2 |
| mse-miR-307 | aPKC, HP19, lysozyme, MLK1, MASK, scolexinB |
| mse-miR-308 | Aop, Atg4LP, βGRP2, Dsor1, HP12, HP8, IKKβ, JAK/Hopscotch, Misshapen, PPBP3, PGRP-L2, PPO1, PI-like, PSP, Rac1, Rel2A, salivary cysteine-rich peptide, serpin4, serpin7, SPH1b, Tab2, TEP1, TEP2, tetraspanin |
| mse-miR-316 | Aop, Argonaute-1, Atg2, aPKC, Domeless, focal adhesion kinase, galectin-2, Hem, HP7, IAP, Lacunin, MEKK1, Rac1, tetraspanin |
| mse-miR-317 | Atg4LP, Draper, Licrone/MKK3, PGRP-L2, PGRP-L5, Ral GTP/GDP exchange factor, MASK, STAT, thioredoxin peroxidase-2 |
| mse-miR-745 | Atg3, IAP, IKKβ, MLK1, Tube |
| mse-miR-750 | CTL10, Ref2P |
| mse-miR-965 | Alk, GTP/GDP exchange factor, MLK1, STAT, TEP1 |
| mse-miR-970 | FADD, hemicentin-2, serpin3, tetraspanin, Tollip |
| mse-miR-989 | Atg4LP, aPKC, nuclear transport factor 2, serpin4, Spz1A, Spz1B, transferrin |
| mse-miR-998 | galectin-2, GTP/GDP exchange factor, p38, protein phosphatase type 2c |
| mse-miR-2755 | Aop, Eiger, PGRP-L2, TEP1 |
| mse-miR-2763 | Alk, ANKRD54, Atg2, Atg3, Atg4, Atg4LP, βGRP2, Domeless, FADD, Hdd13, hemicentin-1, HP14, JAK/Hopscotch, Licrone/MKK3, p38, PAP3, PGRP-L2, PGRP-L5, Phe hydroxylase, PVR, Rel2A, Rel2B, STAT, tetraspanin |
| mse-miR-2766 | ANKRD54, antileukoproteinase, Atg3, Dicer-2, dipeptidyl peptidase, FADD, galectin-4, Hem, hemocyte-specific integrin α2, HP6, HP7, JAK/Hopscotch, Kazal type PI, Lesswright, Licrone/MKK3, MEKK1, Notch, PGRP-L5, PIAS, protein phosphatase type 2c, TEP2, tetraspanin |
| mse-miR-2767 | Aos1, Atg6, cdc42, Draper, Eiger, FADD, HAIP, HP14, HP7, IKKγ, Imd, MEKK1, tyrosine protein kinase |
| mse-miR-2779 | Hdd13, TEP2 |
| mse-miR-6100 | Dopa decarboxylase, MLK1, Punch |
| mse-bantam | galectin-2, p38, PVR, Ubc13/ben |
| mse-miR-iab-4 | Domeless, Dsor1, Hdd13, IAP, lebocinD, MEKK1, PGRP-L5, PSP, Sickie, thioredoxin peroxidase-3 |
| mse-let-7a | cecropin B, Dsor1, leureptin 1, MLK1, serpin4 |
| mse-miR-2a* | Alk, ANKRD54, Atg4, cdc42, Dscam, Imd, PGRP-L2, Ral GTP/GDP exchange factor, SOCS, STAT, thioredoxin peroxidase-2 |
| mse-miR-2b* | Alk, Atg4LP, Atg6, Dredd/Caspase 6, Dsor1, FADD, galectin-4, Hdd1, hemocyte specific integrin α1, HP14, HP4, HP5, IKKp, Integrin β1, JAK/Hopscotch, Jra, leureptin-1, PPBP2, Pelle, PGRP-L5, PGRP-SA, Ras85D, Serrate, tetraspanin, Tollip |
| mse-miR-8* | ANKRD54, Atg2, hemolectin, HP14, HP19, integrin related 1, TAK1, tyrosine hydroxylase, Vrille |
| mse-miR-9a* | Dscam, ECSIT, ERK, Hdd1, IML3, JAK/Hopscotch, Nimrod A, Pellino, PGRP-L2, protein phosphatase type 2c, Rac1, Rel2A, Rel2B |
| mse-miR-9b* | ERK, HP22, JAK/Hopscotch, Nimrod A, Pellino, PGRP-L2, protein phosphatase type 2c, Rac1, Rel2A, Rel2B |
| mse-miR-14* | serpin4 |
| mse-miR-31* | Aos1, βGRP2, Domeless, HP6, HP8, leureptin-1, PGRP-L2, secreted peptide 30 |
| mse-miR-34* | Atg12, Dsor1, ERK, hemocyte specific integrin α1, integrin related 1, PPBP2, Pelle, PI6, MASK, Rel2B, tetraspanin, Tube |
| mse-miR-71* | Domeless, IML3, lebocinD, Licrone/MKK3, MLK1, MASK, Sickie, tetraspanin |
| mse-miR-79* | HP12, JNK, Rac1, serpin6 |
| mse-miR-279a* | Caspar, cdc42, lysozyme, serpin4, Serrate |
| mse-miR-281* | Domeless, hemolectin, Misshapen, Nuclear transport factor 2, serpin4 |
| mse-miR-965* | Atg4LP, hemocyte specific integrin α2, JNK, Rel2B, tyrosine protein kinase |
| mse-miR-2755* | Atg4LP, Dscam, ERK, FADD, Hdd13, HP6, serpin6, SPH4 |
| mse-miR-2766* | Dsor1, Licrone/MKK3 |