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. 2014 Feb 7;4(3):309–312. doi: 10.5681/apb.2014.045

Table 1. Summary of drug-drug/drug-excipient compatibility study.

S.No. Samples Colour and Texture Week Assay (%) % RSD
1 2 3 4
1 Curcumin* Bright yellow-orange powder NSVC 98.43 0.91
2 Piperine* Faint yellow-off-white crystals NSVC 98.98 1.23
3 Quercetin* Yellow-green powder NSVC 99.11 1.98
4 Silibinin* White powder NSVC 99.56 0.63
5 Polymer* White powder NSVC - -
6 Poloxamer 188* White powder NSVC - -
7 ß-cyclodextrin* White powder NSVC - -
8 Curcumin + Piperine@ Bright yellow-orange powder NSVC 97.91 & 98.17 1.39 & 0.86
9 Curcumin + Quercetin@ Yellowish green powder NSVC 98.14 & 100.52 0.76 & 0.63
10 Curcumin + Silibinin@ Bright yellow powder NSVC 99.02 & 98.71 0.49 & 1.59
11 Curcumin + Polymer@ Bright yellow powder NSVC 100.17 1.79
12 Curcumin + Poloxamer@ Bright yellow powder NSVC 99.49 0.61
13 Curcumin + ß-cyclodextrin@ Bright yellow powder NSVC 100.41 0.52
14 Piperine + Polymer@ White to off-white powder NSVC 98.42 0.65
15 Piperine + Poloxamer@ White to off-white powder NSVC 99.83 1.66
16 Piperine + ß-cyclodextrin@ White to off-white powder NSVC 100.10 0.73
17 Quercetin + Polymer@ Faint greenish powder NSVC 98.29 1.19
18 Quercetin + Poloxamer 188@ Faint greenish powder NSVC 97.84 1.21
19 Quercetin + ß-cyclodextrin@ Faint greenish powder NSVC 100.76 0.76
20 Silibinin + Polymer@ White powder NSVC 99.56 0.63
21 Silibinin + Poloxamer 188@ White powder NSVC 98.09 1.55
22 Silibinin + ß-cyclodextrin@ White powder NSVC 100.50 1.75
*Refers to 100 mg of samples; @Refers to 100 mg + 100 mg of samples in combination; NSVC: No significant visual changes; Polymer: Poly(butyl methacrylate-co-(2-dimethylaminoethyl) methacrylate-co-methyl methacrylate)