Table 1.

Summary of Disease Parameters in Preclinical Models^a

	Mouse	Cat	Human
Genotype	LPL−/−	LPLG412R (catalytically inactive mutant)	Multiple
Ad rescue at birth	Yes	No	No
Immune response to hLPL	No	Yes	No
Hypertriglyceridemia	Yes	Yes	Yes
Pancreatitis	No	Yes	Yes
Muscle damage	Yes	No	No

^aThe murine lipoprotein lipase deficiency (LPLD) model exhibits several characteristics distinct from the disease in humans, including a requirement for adenovirus-mediated rescue of LPL expression at birth, preexisting muscle damage and lipid accumulation, and absence of pancreatitis. The feline model more faithfully recapitulates the features of the human disease.

Ad, adenovirus; hLPL, human lipoprotein lipase.