Table 1.

Distribution of NREM and REM sleep of mice during control conditions and nine days of sleep fragmentation

	Light Period	Dark Period	Total 24h
	NREM Sleep
Device	42.1 ± 2.3	24.5 ± 2.5	33.3 ± 1.8
Day 1	32.1 ± 2.1#	22.6 ± 2.4	27.3 ± 1.6
Day 3	35.4 ± 2.0	26.0 ± 2.5	30.7 ± 1.7
Day 9	36.6 ± 2.2	28.1 ± 2.2	32.4 ± 1.5
	REM Sleep
Device	6.8 ± 0.6	3.3 ± 0.5	5.0 ± 0.4
Day 1	0.6 ± 0.1**	3.9 ± 0.5	2.3 ± 0.3**
Day 3	0.5 ± 0.1**	4.4 ± 0.6	2.4 ± 0.3**
Day 9	0.7 ± 0.1**	4.6 ± 0.6	2.7 ± 0.3*
	Total Sleep (NREM + REM)
Device	48.9 ± 2.7	27.7 ± 2.9	38.3 ± 2.2
Day 1	32.7 ± 2.1**	26.5 ± 2.8	29.6 ± 1.8*
Day 3	35.8 ± 2.0**	30.4 ± 3.0	33.1 ± 1.8
Day 9	37.3 ± 2.1**	32.7 ± 2.6	35.0 ± 1.7

Values are mean ± SEM percentage of recording time during the 12 h light and dark periods and the total 24 h period spent in non-rapid eye movement (NREM) sleep, rapid eye movement (REM) sleep, and total sleep (NREM + REM). Recordings were obtained from mice (n=6) housed in the sleep fragmentation device without disk rotation (Device Control) and from the same mice when subjected to disc rotation during the light period for 9 days (Day 1, 3, 9). Data were analyzed using a one-way ANOVA and Tukey’s HSD post hoc multiple comparisons.

Differences from Device control values: # p = 0.054;

^*p < 0.05;

^**p < 0.01.