FIG. 2.

Effect of PYE on systemic inflammatory responses. PYE (10, 50, and 250 mg/kg) was administered orally to mice for seven days before intraperitoneal injection of lipopolysaccharide (LPS; 1.3 mg/kg). Dexamethasone (Dex) was intraperitoneally injected 16 h before LPS stimulation. Serum was obtained 1 h after LPS stimulation, and the levels of TNF-α and IL-6 were measured by enzyme-linked immunosorbant assay (ELISA). Data are expressed as the means±standard deviation (SD; n=9–12). *P<.05, **P<.01, ***P<.005 compared with the control group.