FIG. 6.

Representative histology images of serially cut tissue samples at (A) Day 7; (B) Day 14; (C) Day 21 after implantation. Implanted HUVEC migrated off the surface of the modules and formed blood vessels in the area between the modules (GFP⁺ for donor-derived vessels; CD31⁺ for donor- OR host-derived EC-lined blood vessels). Examples of donor- or host-derived blood vessels are indicated with arrows; examples of host-derived vessels are indicated with (*). Examples of smooth muscle cell invested vessels (SMA⁺) are indicated with arrows; erythrocyte-containing vessels are also indicated with arrows. Insets show details of inside space of vessels. Scale bar is 100 μm for lower magnification images and 50 μm for higher magnification. Black squares indicate areas that are shown in higher magnification images. Circle highlights one individual module. SMA, smooth muscle actin. Color images available online at www.liebertpub.com/tea