Table 4.
Selected copy number imbalances predicting breast cancer site specific non-bone metastasis, from the CoxBoost analysis in the discovery
| CNI marker | Lung metastasis (n = 59)
|
Liver metastasis (n = 35)
|
Brain metastasis (n = 47) #
|
|||
|---|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
| 2p11.2 gain | 4.56 (1.83–11.42) | 0.0012 | 1.75 (0.24–11.81) | 0.5811 | 5.43 (2.14–13.75) | 0.0004 |
| 3q21.3–22.2 gain | 4.90 (2.32–10.32) | 2.96 × 10−5 | 0 (0-Infinity) | — | 4.87 (2.06–11.51) | 0.0003 |
| 3q27.1 gain | 3.50 (1.82–6.74) | 0.0002 | 1.00 (0.24–4.18) | 0.9965 | 4.54 (2.31–8.92) | 1.16 × 10−5 |
| 7q21.11 loss | 3.13 (0.76–12.83) | 0.113 | 2.97 (0.41–21.71) | 0.2839 | 4.31 (1.04–17.81) | 0.0435 |
| 10q23.1 gain | 4.03 (1.73–9.37) | 0.0012 | 2.22 (0.53–9.28) | 0.2734 | 2.34 (0.73–7.56) | 0.154 |
| 11q13.5 gain | 1.45 (0.58–3.63) | 0.4281 | 2.40 (0.93–6.2) | 0.07 | 3.64 (1.76–7.56) | 0.0005 |
| 14q13.2–3 gain | 3.94 (1.93–8.01) | 0.0002 | 1.53 (0.37–6.38) | 0.5608 | 3.05 (1.20–7.72) | 0.0187 |
Abbreviations: CNI, copy number imbalance; HR, hazard ratio; CI, confidence interval.
#
Because there were only 9 patients with first metastasis to brain, we expanded this group to include those with any brain metastasis to improve the power.