FIG 3.

Survival rates (A) and body weight (B) changes of mice immunized at different times prior to virus infection. Immunized mice received imiquimod (50 μg) and PANENZA vaccine (3 μg of HA) in combination (VCI) on day −3 (⧫), day −2 (*), day −1 (▲), or day 0 (×). Control mice received PBS on day −3 (□). On the day of infection (day 0), mice were infected with 10 times the mouse LD₅₀ of mouse-adapted A(H1N1)pdm09 virus and monitored for 14 days. n = 20 to 30 per group. Results are mean data from five experiments. Error bars indicate standard deviations. **, P < 0.01 (compared with the PBS group).