TABLE 1.
GMTs of serum antibodies
| Group | GMTa at: |
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Day 1 p.i. |
Day 2 p.i. |
Day 4 p.i. |
Day 6 p.i. |
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| HAI | MN | IgM | IgG | HAI | MN | IgM | IgG | HAI | MN | IgM | IgG | HAI | MN | IgM | IgG | |
| VCI day −3 | <10 | <10 | 151c (3/5) | 500c (4/5) | <10 | <10 | 348d (5/5) | 1516d (5/5) | <10 | 13d (1/8) | 951c (8/8) | 5657d (8/8) | 269 (8/8) | 494c (8/8) | 4526d (8/8) | 20749d (8/8) |
| VCI day −2 | NDb | ND | <200 | <500 | <10 | <10 | 152 (3/5) | <500 (0/5) | <10 | <10 | 696c (5/5) | 1,149 (5/5) | 226 (6/6) | 202 (6/6) | 2,851 (6/6) | 8,000 (6/6) |
| VCI day −1 | ND | ND | <200 | <500 | <10 | <10 | 174 (4/5) | <500 (0/5) | <10 | <10 | 303 (5/5) | 758 (5/5) | 211 (5/5) | 160 (5/5) | 1,393 (6/6) | 4,000 (5/5) |
| Vaccine day −3 | ND | ND | <200 | <500 | <10 | <10 | 174 (4/5) | 435 (3/5) | <10 | <10 | 336 (8/8) | 1,682 (8/8) | 119 (6/7) | 54 (5/7) | 1,600 (7/7) | 4,876 (6/7) |
| Imiquimod day −3 | ND | ND | <200 | <500 | <10 | <10 | <200 | <500 | <10 | <10 | <200 | 500 (3/8) | 10 (2/8) | 11 (2/8) | 200 (5/8) | 1,834 (7/8) |
| PBS | <10 | <10 | <200 | <500 | <10 | <10 | <200 | <500 | <10 | <10 | <200 | <500 | <10 | <10 | 119 (3/9) | 354 (3/9) |
a
An HAI assay titer of ≥1:40 was considered positive. Vaccine day −3, vaccine alone given 3 days prior to virus infection. An MN assay titer of ≥1:40 was considered positive. The values in parentheses are the number positive/number tested.
b
ND, not done.
c
P < 0.01 compared with the vaccine-alone group (Mann-Whitney U test).
d
P < 0.05 compared with the vaccine-alone group (Mann-Whitney U test).