TABLE 1.
Spontaneous drug-resistant T. rubrum mutants obtained following direct selection on plates containing inhibitory drug concentrations
| Strain | Parametera | Value |
|||
|---|---|---|---|---|---|
| Terbinafine | Itraconazole | Amorolfine | Ciclopirox | ||
| ATCC 28188 | Total no. of CFU plated | 7.2 × 108 | 7.2 × 108 | 7.2 × 108 | 7.2 × 108 |
| No. of resistant colonies | 1 | 490 | 3 | 0 | |
| Resistance frequency | 1.4 × 10−9 | 6.8 × 10−7 | 4.1 × 10−9 | <1.4 × 10−9 | |
| CI-1 | Total no. of CFU plated | 8.7 × 108 | 8.7 × 108 | 8.7 × 108 | 8.7 × 108 |
| No. of resistant colonies | 0 | 654 | 1 | 0 | |
| Resistance frequency | <1.1 × 10−9 | 7.5 × 10−7 | 1.1 × 10−9 | <1.1 × 10−9 | |
| CI-2 | Total no. of CFU plated | 6.9 × 108 | 6.9 × 108 | 6.9 × 108 | 6.9 × 108 |
| No. of resistant colonies | 2 | 205 | 4 | 0 | |
| Resistance frequency | 2.9 × 10−9 | 3.0 × 10−7 | 5.8 × 10−9 | <1.4 × 10−9 | |
a
Resistance frequency data were calculated by dividing the number of CFU grown on the plates containing each drug by the total number of CFU spread on plates.