TABLE 2.
In vitro evolution of drug resistance in T. rubrum following exposure to subinhibitory drug concentrations for 5 or 10 transfers before selection
| Strain | Transfer | Resistance frequencya |
|||
|---|---|---|---|---|---|
| Terbinafine | Itraconazole | Amorolfine | Ciclopirox | ||
| ATCC 28188 | 5th | 1.3 × 10−7 | 9.6 × 10−5 | <1.5 × 10−8 | <6.0 × 10−9 |
| 10th | 9.1 × 10−6 | 2.4 × 10−4 | 2.2 × 10−8 | <1.3 × 10−8 | |
| CI-1 | 5th | <5.2 × 10−8 | 9.0 × 10−6 | <3.4 × 10−8 | <1.7 × 10−8 |
| 10th | 4.4 × 10−7 | 2.6 × 10−5 | 9.1 × 10−8 | <1.2 × 10−8 | |
a
Resistance frequency data were calculated by dividing the number of CFU grown on the plates containing each drug by the total number of CFU spread on plates.